Phyllis
Zee |
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Age-related changes of the circadian system and sleep; genetics of sleep and circadian rhythm disorders We are interested in how aging alters the circadian clock system of mammals and its relationship to circadian rhythm and sleep disorders in humans. Our laboratory performs basic research with animals, as well as clinical research with humans. Our basic science studies involve an examination of the neurochemical events which underlie aging of the circadian clock. A variety of pharmacological approaches are used to restore the responsiveness of the circadian system to light. In the clinical setting, we are quantifying exposure to synchronizing agents for the circadian clock in elderly patients to determine whether exposure to scheduled bright light and structured activity cycles will lead to an improvement in performance, mood, daytime alertness, and sleep. It is hoped that the combined basic science and
clinical approach will lead to important information which can be used
to improve nocturnal
sleep, daytime performance, and overall quality of life in older adults. |
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Professor MD, PhD, Chicago Medical School |
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e-mail
Dr. Zee |
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| Selected References: • Blei, A.T. and Zee, P.C. (1998) Abnormalities of circadian rhythmicity in liver disease. J. Hepatol. 29:832-835. • Labyak, S.E., Turek, F.W., Wallen, E.P. and Zee,
P.C. (1998) Effects of bright light on age-related changes in the locomotor
activity activity
of Syrian hamsters. Am.J.Physiol. 274:R830-839. • Penev, P.D., Zee, P.C. and Turek, F.W. (1997) Serotonin in the spotlight. Nature 385:123. |
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