Age-related changes of the circadian system and sleep; genetics of sleep and circadian rhythm disorders

We are interested in how aging alters the circadian clock system of mammals and its relationship to circadian rhythm and sleep disorders in humans. Our laboratory performs basic research with animals, as well as clinical research with humans.

Our basic science studies involve an examination of the neurochemical events which underlie aging of the circadian clock. A variety of pharmacological approaches are used to restore the responsiveness of the circadian system to light. In the clinical setting, we are quantifying exposure to synchronizing agents for the circadian clock in elderly patients to determine whether exposure to scheduled bright light and structured activity cycles will lead to an improvement in performance, mood, daytime alertness, and sleep.

It is hoped that the combined basic science and clinical approach will lead to important information which can be used to improve nocturnal sleep, daytime performance, and overall quality of life in older adults.

e-mail Dr. Zee
ph: 312.908.8549
fax: 312.908.5073

• Ouyang F, Lu BS, Wang B, Yang J, Li Z, Wang L, Tang G, Xing H, Xu X, Chervin RD, Zee PC, Wang X. (2008) Sleep patterns among rural Chinese twin adolescents. Sleep Med. Aug 25. [Epub ahead of print]

• Zee PC. (2008) Melantonin for the treatment of advanced sleep phase disorder. Sleep. 31(7):923; author reply 925.

• Mander BA, Reid KJ, Davuluri VK, Small DM, Parrish TB, Mesulam MM, Zee PC, Gitelman DR. (2008) Sleep deprivation alters functioning within the neural network underlying the covert orienting of attention. Brain Res. 1217:148-56.

• Yu Y, Lu BS, Wang B, Wang H, Yang J, Li Z, Wang L, Liu X, Tang G, Xing H, Xu X, Zee PC, Wang X. (2007) Short sleep duration and adiposity in Chinese adolescents. Sleep. 30(12):1688-97.

Other Links:

• Northwestern University Medical School Department of Neurology