William
Klein |
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Cell
and structural biology of Alzheimer’s disease; memory-linked
synapse structure and signal transduction |
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Professor PhD, UCLA |
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e-mail
Dr. Klein |
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Selected References: • McKee AC, Carreras I, Hossain L, Ryu H, Klein WL, Oddo S, LaFerla FM, Jenkins BG, Kowall NW, Dedeoglu A. (2008) Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice. Brain Research. 1207:225-36. • Viola KL, Velasco PT, Klein WL. (2008) Why Alzheimer's is a disease of memory: the attack on synapses by A beta oligomers (ADDLs). J Nutr Health Aging. 12(1):51S-7S. Review. • Durairajan SS, Yuan Q, Xie L, Chan WS, Kum WF, Koo I, Liu C, Song Y, Huang JD, Klein WL, Li M. (2008) Salvianolic acid B inhibits Abeta fibril formation and disaggregates preformed fibrils and protects against Abeta-induced cytotoxicty. Neurochem Int. 52(4-5):741-50. • Zhao WQ, De Felice FG, Fernandez S, Chen H, Lambert MP, Quon MJ, Krafft GA, Klein WL. (2008) Amyloid beta oligomers induce impairment of neuronal insulin receptors. FASEB J. 22(1):246-60. • De Felice FG, Wasilewska-Sampaio AP, Barbosa AC, Gomes FC, Klein WL, Ferreira ST. (2007) Cyclic AMP enhancers and Abeta oligomerization blockers as potential therapeutic agents in Alzheimer's disease. Curr Alzheimer Res. 4(3):263-71. Review. • De Felice FG, Lambert MP, Viola KL, Velasco PT, Fernandez SJ, Ferreira ST, Klein WL. (2007) Aβ oligomers induce neuronal oxidative stress through an NMDA receptor-dependent mechanism that is blocked by the Alzheimer's drug memantine. J Biol Chem. 282(15):11590-601. • De Felice FG, Wu D, Lambert MP, Fernandez SJ, Velasco PT, Lacor PN, Bigio EH, Jerecic J, Acton PJ, Shughrue PJ, Chen-Dodson E, Kinney GG, Klein WL. (2007) Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers. Neurobiol. Aging. [Epub ahead of print] • Georganopoulou DG, Chang L, Klein WL, and Mirkin CA. (2005) Nanoparticle-based detection of a soluble pathogenic biomarker for Alzheimer’s Disease. Proc Natl Acad Sci, 102(7): 2273-6. • Lacor PN, Buniel MC, Gong Y, Chang L, Viola KL, Lambert MP, Velasco PT, Bigio EH, Finch CE, Krafft GA, and Klein WL. (2004) Synaptic targeting by Alzheimer’s related Aβ oligomers. J Neurosci, 24:10191-10200. • Gong Y, Chang L, Viola KL, Lacor PN, Lambert MP, Finch CE, Krafft GA, and Klein WL. (2003) Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proc Natl Acad Sci USA, 100(18):10417-10422. • Lambert MP, Barlow AK, Chromy B, Edwards C, Freed F, Liosatos M, Morgan TE, Rozovsky I, Trommer B, Viola KL, Wals P, Zhang C, Finch CE, Krafft GA, and Klein WL. (1998) Diffusible, nonfibrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci 95:6448-6453. *Please Note: By clicking on the above links, a .pdf may be downloaded to your desktop. |
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