[audio: Dr. Buchman discusses possible treatments for Crohn's disease]

MEDIA CONTACT: Elizabeth Crown at (312) 503-8928 or at e-crown@northwestern.edu

August 7, 2002

Crohn’s Disease Therapies Tested

Alan Buchman, M.D.

CHICAGO --- Researchers at The Feinberg School of Medicine at Northwestern University are conducting clinical trials of several innovative approaches to the treatment of Crohn’s disease, including experimental drugs and a new swallowable video camera that produces high-quality images of the small intestine.

In addition to aiding diagnosis by affording a more complete view of the small intestine without pain or discomfort to the patient, the "camera-in-a-capsule" enables physicians to direct appropriate treatment and determine the effect of new medications for Crohn’s disease.

The studies are headed by Alan Buchman, M.D., associate professor of medicine at The Feinberg School and director of the Inflammatory Bowel Disease Center at Northwestern.

Crohn’s is a serious inflammatory disease of the gastrointestinal tract that causes diarrhea, abdominal cramps, fever and rectal bleeding. The cause of Crohn’s disease is unknown.

Among the experimental medications for Crohn’s disease undergoing investigation at Northwestern is a synthetic, oral form of interleukin-11, a chemical produced by white blood cells in response to inflammation. This study of interleukin-11 for Crohn’s disease is the first to be conducted in humans.

Research has shown that interleukin-11 is both an anti-inflammatory agent and a potent growth factor that aids in the healing process. Other drugs used to treat Crohn’s disease, such as prednisone, only reduce inflammation.

In a separate study, Northwestern also is assessing the use of interleukin-11 in ulcerative colitis.

Northwestern will be studying two experimental drugs for Crohn’s disease that prevent inflammation by blocking the process by which white blood cells adhere to areas of inflammation in the bowel.

Another investigational study for Crohn’s disease will focus on a drug that blocks production of an inflammation-causing chemical known as tumor necrosis factor.

For information on these and other studies for the treatment of Crohn’s disease and ulcerative colitis, contact the Northwestern Inflammatory Bowel Disease Center at (312) 695-4IBD (or 4423).