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Teresa
Woodruff |
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Regulation of Ovarian Follicle Growth during the Mammalian Reproductive Cycles The primary goal of the laboratory is to understand the biological, cellular, and molecular mechanisms that regulate the reproductive axis. Our approach requires an integrated view of the axis as a whole; however, emphasis is placed on ovarian-regulated events. We seek to understand the hormonal signals produced by the ovaries, the mechanics of follicular growth, the hormonal and neuronal effectors of follicle selection and maturation, the factors involved in the development of oocytes, the events surrounding follicle wall rupture and wound healing, and the interplay between oocyte and somatic cells. Our scientific approach toward an understanding of ovarian-directed reproductive events is to identify and study factors produced by the ovary which regulate local and distal events. |
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Professor PhD, Northwestern |
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e-mail
Dr. Woodruff |
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| Selected References: • Cook RW, Thompson TB, Kurup SP, Jardetzky TS, Woodruff TK. 2005. Structural basis for a functional anatagonist in the TGFbeta superfamily. J Biol Chem. 2005 Sept 26. • Thompson TB, Lerch TF, Cook RW, Woodruff TK, Jardetzky TS 2005. Antagonism of Both Type I and Type II Receptor Binding. Dev Cell 9(4); 535-43. • Suszko MI, Balkin DM, Chen Y, Woodruff TK 2005. Smad3 mediates Activin-induced transcription of follicle-stimulating hormone {beta} - subunit gene. Mol Endocrinol 19(7); 1849-58. |
Other
Links: • Center for Reproductive Research at Northwestern University (SCCPRR) • The Robert H. Lurie Comprehensive Cancer Center of Northwestern University • Center for Reproductive Science • Center for Families after Cancer
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