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Joseph S. Takahashi
Walter and Mary Elizabeth Glass Professor, Howard Hughes Medical Institute
PhD, Oregon
  Expanded links and resources:
e-mail Dr. Takahashi
ph: 847.491.4598
fax: 847.491.4600

HHMI Holiday Lectures on Science

 

References:

  1. Menaker, M., J.S. Takahashi and A. Eskin.  1978.  The physiology of circadian pacemakers.  Annual Review of Physiology 40:501-526.

  2. Takahashi, J.S., C. Norris and M. Menaker.  1978.  Circadian photoperiodic regulation of testis growth in the house sparrow: Is the pineal gland involved?  In: Comparative Endocrinology, P.J. Gaillard and H.H. Boer (eds.), Elsevier/North-Holland Biomedical Press, Amsterdam, pp. 153-156.

  3. Takahashi, J.S. and M. Menaker.  1979.  Physiology of avian circadian pacemakers. Federation Proceedings 38:2583-2588.

  4. Takahashi, J.S. and M. Menaker.  1979.  Brain mechanisms in avian circadian  systems.  In: Biological Rhythms and Their Central Mechanism, M. Suda, O. Hayaishi and H. Nakagawa (eds.), Elsevier/North-Holland Biomedical Press, pp. 95-109.

  5. Takahashi, J.S. and M. Menaker.  1980.  On the organization of avian circadian systems: The role of the pineal and suprachiasmatic nuclei.  In: Acta XVII Congressus  Internationalis Ornithologici  Vol. I, R. Nohring (ed.), Deuschen Ornithologen-Gesellschaft, Berlin, pp. 425-434.

  6. Takahashi, J.S., H. Hamm and M. Menaker.  1980.  Circadian rhythms of melatonin release from individual superfused chicken pineal glands in vitro. Proc. Natl. Acad. Sci. USA 77:2319-2322.

  7. Takahashi, J.S. and M. Menaker.  1980.  Interaction of estradiol and progesterone: Effects on the circadian locomotor rhythm of female golden hamsters.  American Journal of Physiology 239:R497-R504.

  8. Menaker, M., D.J. Hudson and J.S. Takahashi.  1981.  Neural and endocrine components of circadian clocks in birds.  In: Biological Clocks in Seasonal Reproductive Cycles, B.K. Follett and D.E. Follett (eds.), John Wright and Sons Ltd., Bristol, pp. 171-183.

  9. Takahashi, J.S.  1982.  Neural mechanisms in avian circadian systems: Hypothalamic pacemaking systems.  In: Vertebrate Circadian Systems, J. Aschoff, S. Daan and G. Groos (eds.), Springer-Verlag, Berlin, Heidelburg, pp. 112-119.

  10. Takahashi, J.S.  1982.  Circadian rhythms of the isolated chicken pineal in vitro.  In: Vertebrate Circadian Systems, J. Aschoff, S. Daan and G. Groos (eds.), Springer-Verlag, Berlin, Heidelburg, pp. 158-163.

  11. Takahashi, J.S. and M. Menaker.  1982.  Entrainment of the circadian system of the house sparrow: A population of oscillators in pinealectomized birds.  Journal of Comparative Physiology 146:245-253.

  12. Takahashi, J.S. and M. Menaker.  1982.  Role of the suprachiasmatic nuclei in the circadian system of the house sparrow, Passer domesticus.  Journal of Neuroscience 2:815-828.

  13. Takahashi, J.S. and M. Zatz.  1982.  Regulation of circadian rhythmicity.  Science   217:1104-1111.

  14. Hamm, H., J.S. Takahashi and M. Menaker.  1983.  Light-induced decrease of serotonin N-acetyltransferase activity and melatonin in the chicken pineal gland and retina.  Brain Research 266:287-293.

  15. Eskin, A. and J.S. Takahashi.  1983.  Adenylate cyclase activation shifts the phase of a circadian pacemaker.  Science 220:82-84.

  16. Takahashi, J.S. and M. Menaker.  1984.  Circadian rhythmicity: Regulation in the time domain.  In: Biological Regulation and Development, Vol. 3B, R.F.
    Goldberger and K.R. Yamamoto (eds.), Plenum Press, New York, pp. 285-303.

  17. Takahashi, J.S. and M. Menaker.  1984.  Multiple redundant circadian oscillators within the isolated avian pineal gland.  Journal of Comparative Physiology A 154:435-440.

  18. Takahashi, J.S., P.J. DeCoursey, L. Bauman and M. Menaker.  1984.  Spectral sensitivity of a novel photoreceptive system mediating entrainment of mammalian circadian rhythms.  Nature (London) 308:186-188.

  19. Reisine, T.D. and J.S. Takahashi.  1984.  Somatostatin pretreatment desensitizes somatostatin receptors linked to adenylate cyclase and facilitates the stimulation of cyclic adenosine 3':5'-monophosphate accumulation in mouse anterior pituitary tumor cells.  Journal of Neuroscience 4:812-819.

  20. Eskin, A., J.S. Takahashi, M. Zatz and G.D. Block.  1984.  Cyclic guanosine 3':5'-monophosphate mimics the effects of light on a circadian pacemaker in the eye of Aplysia.  Journal of Neuroscience 4:2466-2471.

  21. Dubocovich, M.L., R.C. Lucas and J.S. Takahashi.  1985.  Light-dependent regulation of dopamine receptors in mammalian retina.  Brain Research 335:321-325.

  22. Dubocovich, M.L., R.C. Lucas and J.S. Takahashi.  1986.  Constant-light induced down-regulation of dopamine receptors in retina.  In: Dopaminergic Systems and Their Regulation, G.N. Woodruff, J.A. Poat and P.J. Roberts (eds.), MacMillan Press, England, pp. 429-430.

  23. Cassone, V.M., J.S. Takahashi, C.D. Blaha, R.F. Lane and M. Menaker.  1986.  Dynamics of noradrenergic circadian input to the chicken pineal gland.  Brain Research 384:334-341.

  24. Duncan, M.J., J.S. Takahashi and M.L. Dubocovich.  1986. Characterization of 2-[125I]-iodomelatonin binding sites in hamster brain.  European Journal of Pharmacology 132:333-334.

  25. Keefe, D.L., D.J. Earnest, D. Nelson, J.S. Takahashi and F.W. Turek.  1987.  A cholinergic antagonist, mecamylamine, blocks the phase-shifting effects of light on the circadian rhythm of locomotor activity in the golden hamster.  Brain Research 403:308-312.

  26. Takahashi, J.S. and F.W. Turek.  1987.  Anisomycin, an inhibitor of protein synthesis, perturbs the phase of a mammalian circadian pacemaker.  Brain Research 405:199-203.

  27. Dubocovich, M.L. and J.S. Takahashi.  1987.  Use of 2-[125I]-iodomelatonin to characterize melatonin binding sites in chicken retina. Proc. Natl. Acad. Sci. USA 84:3916-3920.

  28. Pratt, B.L. and J.S. Takahashi.  1987.  Alpha-2 adrenergic receptor regulation of melatonin release in chick pineal cell cultures.  Journal of Neuroscience 7:3665-3674.

  29. Takahashi, J.S.  1987.  Cellular basis of circadian rhythms in the avian pineal.  In: Comparative Aspects of Circadian Clocks, T. Hiroshige and K. Honma (eds.), Hokkaido University Press, Sapporo, pp. 3-15.

  30. Robertson, L.M. and J.S. Takahashi.  1988.  Circadian clock in cell culture: I. Oscillation of melatonin release from dissociated chick pineal cells in flow-through microcarrier culture.  Journal  of Neuroscience 8:12-21.

  31. Robertson, L.M. and J.S. Takahashi.  1988.  Circadian clock in cell culture: II. In vitro entrainment to light of melatonin oscillation from dissociated chick pineal cells.  Journal of Neuroscience 8:22-30.

  32. Duncan, M.J., J.S. Takahashi and M.L. Dubocovich.  1988.  2-[125I]-Iodomelatonin binding sites in hamster brain membranes: Pharmacological characteristics and regional distribution.  Endocrinology 122:1825-1833.

  33. Pratt, B.L. and J.S. Takahashi.  1988.  A pertussis toxin-sensitive G protein mediates the a2-adrenergic receptor inhibition of melatonin release in photoreceptive chick pineal cell cultures.  Endocrinology 123:277-283.

  34. Inouye, S.T., J.S. Takahashi, F. Wollnik and F.W. Turek.  1988.  Inhibitor of protein synthesis phase shifts a circadian pacemaker in mammalian SCN.  American Journal of Physiology 255:R055-R1058.

  35. Takahashi, J.S., D.E. Nelson and A. Eskin.  1989.  Immunocytochemical localization of serotonergic fibers innervating the Aplysia ocular circadian system.  Neuroscience 28:139-147.

  36. Pierce, M.E., D. Barker, J. Harrington and J.S. Takahashi.  1989.  Cyclic AMP-dependent melatonin production in Y79 human retinoblastoma cells.  Journal of Neurochemistry 53:307-310.

  37. Hamm, H.E., D. Deretic, M.R. Mazzoni, C.A. Moore, J.S. Takahashi and M.M. Rasenick.  1989.  A monoclonal antibody against the rod outer segment guanyl nucleotide-binding protein, transducin, blocks the stimulatory and inhibitory G-proteins of adenylate cyclase.  Journal of Biological Chemistry 264:1475-1482.

  38. Duncan, M.J., J.S. Takahashi and M.L. Dubocovich.  1989.  Characteristics and autoradiographic localization of 2-[125I]-iodomelatonin binding sites in Djungarian hamster brain.  Endocrinology 125:1011-1018.

  39. Wollnik, F., F.W. Turek, P. Majewski and J.S. Takahashi.  1989.  Phase shifting the circadian clock with cycloheximide: Response of hamsters with an intact or split rhythm of locomotor activity.  Brain Research 496:82-88.

  40. Takahashi, J.S., N. Murakami, S.S. Nikaido, B.L. Pratt and L.M. Robertson.  1989.  The avian pineal, a vertebrate model system of the circadian oscillator: Cellular regulation of circadian rhythms by light, second messengers and macromolecular synthesis.  Recent  Progress in Hormone Research 45:279-352.

  41. Pratt, B.L. and J.S. Takahashi.  1989.  Vasoactive intestinal polypeptide (VIP) and a2-adrenoceptor agonists regulate cAMP accumulation and melatonin release in chick pineal cell cultures.  Endocrinology 125:2375-2384.

  42. Nikaido, S.S. and J.S. Takahashi.  1989.  Twenty-four hour oscillation of cAMP in chick pineal cells: Role of cAMP in the acute and circadian regulation of melatonin production.  Neuron  3:609-619.

  43. Milette, J.J., J.S. Takahashi and F.W. Turek.  1990.  The photic threshold for photoperiodic stimulation of neuroendocrine-gonadal activity in male Djungarian hamsters.  Brain Research 512:304-308.

  44. Kornhauser, J.M., D.E. Nelson, K.E. Mayo and J.S. Takahashi.  1990.  Photic and circadian regulation of c-fos gene expression in the hamster suprachiasmatic nucleus.  Neuron  5:127-134.

  45. Janavs, J.L., M.E. Pierce and J.S. Takahashi.  1991.  N-acetyltransferase and protein synthesis modulate melatonin production in Y79 human retinoblastoma cells.  Brain Research 540:138-144.

  46. Nelson, D.E. and J.S. Takahashi.  1991.  Sensitivity and integration in a visual pathway for circadian entrainment in the hamster, Mesocricetus auratus.  Journal of Physiology  (London) 439:115-145.

  47. Nelson, D.E. and J.S. Takahashi.  1991.  Comparison of visual sensitivity for suppression of pineal melatonin and circadian phase shifting in the golden hamster.  Brain Research  554:272-277.

  48. Takahashi, J.S.  1991.  Circadian rhythms: From gene expression to behavior.  Current Opinion in Neurobiology 1:556-561.

  49. Kornhauser, J.M., D.E. Nelson, K.E. Mayo and J.S. Takahashi.  1992.  Light regulates c-fos gene expression in the hamster SCN: Implications for circadian and seasonal control of reproduction.  In: Follicle Stimulating Hormone: Regulation of Secretion and Molecular Mechanisms of Action, M. Hunzicker-Dunn and N.B. Schwartz (eds.), Serono Symposia USA, Springer-Verlag, pp. 95-106.

  50. Smith, R.D., F.W. Turek and J.S. Takahashi.  1992.  Two families of phase-response curves characterize the resetting of the hamster circadian clock.  American Journal of Physiology  262:R1149-R1153.

  51. Kornhauser, J.M., D.E. Nelson, K.E. Mayo and J.S. Takahashi.  1992.  Regulation of jun-B messenger RNA and AP-1 activity by light and a circadian clock.  Science  255:1581-1584.

  52. Takahashi, J.S.  1992.  Circadian clock genes are ticking.  Science  258:238-240.

  53. Kornhauser, J.M., K.E. Mayo and J.S. Takahashi.  1993.  Immediate-early gene expression in a mammalian circadian pacemaker: the suprachiasmatic nucleus.  In: Molecular Genetics of Biological Rhythms.  M.W. Young (ed.), Marcel Dekker, New York, pp. 271-307.

  54. Takahashi, J.S., J.M. Kornhauser, C. Koumenis and A. Eskin.  1993.  Molecular approaches to understanding circadian oscillations.  Annual Review of Physiology  55:729-753.

  55. Pierce, M.E., H.K. Sheshberadaran, Z. Zhang, L.E. Fox, M.L. Applebury and J.S. Takahashi.  1993.  Circadian regulation of iodopsin gene expression in embryonic photoreceptors in retinal cell culture.  Neuron  10:579-584.

  56. Zhang, Y., P.C. Zee, J.D. Kirby, J.S. Takahashi and F.W. Turek.  1993.  A cholinergic antagonist, mecamylamine, blocks light-induced Fos immunoreactivity in specific regions of the hamster suprachiasmatic nucleus.  Brain Research  615:107-112.

  57. Ginty, D.D., J.M. Kornhauser, M.A. Thompson, H. Bading, K.E. Mayo, J.S. Takahashi and M.E. Greenberg.  1993.  Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock.  Science 260:238-241.

  58. Takahashi, J.S.  1993.  Circadian-clock regulation of gene expression.  Current Opinion in Genetics & Development 3:301-309.

  59. Takahashi, J.S.  1993.  Biological rhythms: From gene expression to behavior.  In: Light and Biological Rhythms, L. Wetterberg (ed.), Pergamon Press, Oxford, UK, pp. 3-20.

  60. Takahashi, J.S.  1993.  Gene regulation: Circadian clocks à la CREM.  Nature News and Views  365:299-300.

  61. Zhang, Y., O. Van Reeth, P.C. Zee, J.S. Takahashi and F.W. Turek.  1993.  Fos protein expression in the circadian clock is not associated with phase shifts induced by a nonphotic stimulus, triazolam.  Neuroscience Letters  164:203-208.

  62. Takahashi, J.S.  1994.  Circadian rhythms: ICER is nicer at night (sir!).  Current Biology  4:165-168. 

  63. Janavs, J.L., M.E. Pierce and J.S. Takahashi.  1994.  RNA synthesis inhibitors increase melatonin production in Y79 human retinoblastoma cells.  Molecular Brain Research 23:47-56.

  64. 1Vitaterna, M.H., D.P. King, A.-M. Chang, J.M. Kornhauser, P.L. Lowrey, J.D. McDonald, W.F. Dove, L.H. Pinto, F.W. Turek and J.S. Takahashi.  1994.  Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior.  Science 264:719-725.

  65. Takahashi, J.S., L.H. Pinto and M.H. Vitaterna.  1994.  Forward and reverse genetic approaches to behavior in the mouse.  Science 264:1724-1733.

  66. Sheshberadaran, H.K. and J.S. Takahashi.  1994.  Characterization of the chicken rhodopsin promoter: Identification of retina-specific and glass-like protein binding domains.  Molecular and Cellular Neurosciences 5:309-318.

  67. Besecke, L.M., A.M. Wolfe, M.E. Pierce, J.S. Takahashi and J.E. Levine.  1994.  Neuropeptide Y (NPY) stimulates luteinizing hormone-releasing hormone (LHRH) release from superfused hypothalamic GT1-7 cells.  Endocrinology 135:1621-1627.

  68. Turek, F.W., P. Penev, Y. Zhang, O. Van Reeth, J.S. Takahashi and P.C. Zee.  1995.  Alterations in circadian system in advanced age.  In: Circadian Clocks and Their Adjustment.  Ciba Foundation Symposium, Wiley, Chichester, pp. 212-234.

  69. Janavs, J.L., J.C. Florez, M.E. Pierce and J.S. Takahashi.  1995.  Forskolin and camptothecin induce a 30 kDa protein associated with melatonin production in Y79 human retinoblastoma cells.  Journal of Neuroscience 15:298-309.

  70. Max, M., P.J. McKinnon, K.J. Seidenman, R.K. Barrett, M.L. Applebury, J.S. Takahashi and R.F. Margolskee.  1995.  Pineal opsin: A nonvisual opsin expressed in chick pineal.  Science 267:1502-1506.

  71. Takahashi, J.S.  1995.  Molecular neurobiology and genetics of circadian rhythms in mammals.  Annual Review of Neuroscience 18:531-553.

  72. Menaker, M. and J.S. Takahashi.  1995.  Genetic analysis of the circadian system of mammals: Properties and prospects.  Seminars in the Neurosciences 7:61-70.

  73. Takahashi, J.S. and M. Hoffman.  1995.  Molecular biological clocks.  American Scientist 83:158-165.

  74. Florez, J.C. and J.S. Takahashi.  1995.  The circadian clock: from molecules to behavior.  Annals of Medicine 27:481-490.

  75. Barrett, R.K. and J.S. Takahashi.  1995.  Temperature compensation and temperature entrainment of the chick pineal cell circadian clock.  Journal  of Neuroscience 15:5681-5692.

  76. Turek, F.W., L.H. Pinto, M.H. Vitaterna, P. Penev, P. Zee and J.S. Takahashi.  1995.  Pharmacological and genetic approaches for the study of circadian rhythms in mammals.  In: Frontiers in Neuroendocrinology 16:191-223.

  77. Florez, J.C. and J.S. Takahashi.  1996.  Biological rhythms and the pineal gland.  In: Comprehensive Human Physiology, Vol. 1.  R. Greger and U. Windhorst (eds.), Springer-Verlag, Berlin, pp. 1199-1214.

  78. Kornhauser, J.M., K.E. Mayo and J.S. Takahashi.  1996.  Light, immediate-early genes, and circadian rhythms.  Behavior Genetics 26:221-240. 

  79. Zhang, Y., J.M. Kornhauser, P.C. Zee, K.E. Mayo, J.S. Takahashi and F.W. Turek.  1996.  Effects of aging on light-induced phase-shifting of circadian behavioral rhythms, Fos expression, and CREB phosphorylation in the hamster suprachiasmatic nucleus.  Neuroscience 70:951-961.

  80. Florez, J.C. and J.S. Takahashi.  1996.  Quantitative two-dimensional gel electrophoretic analysis of clock-controlled proteins in cultured chick pineal cells: Circadian regulation of tryptophan hydroxylase.  Journal of Biological Rhythms 11:241-257.

  81. Nikaido, S.S. and J.S. Takahashi.  1996.  Calcium modulates circadian variation in cAMP-stimulated melatonin in chick pineal cells.  Brain Research 716:1-10.

  82. Florez, J.C. and J.S. Takahashi.  1996.  Regulation of tryptophan hydroxylase by cyclic AMP, calcium, norepinephrine and light in cultures of chick pineal cells.  Journal of Neurochemistry 67:242-250.

  83. Takahashi, J.S.  1996.  Circadian rhythms: Ion channels get the message.  Nature News and Views 382:117-118.

  84. Florez, J.C., K.J. Seidenman, R.K. Barrett, A.M. Sangoram and J.S. Takahashi.  1996.  Molecular cloning of chick pineal tryptophan hydroylase and circadian oscillation of its mRNA levels.  Molecular Brain Research 42:25-30.

  85. Wisor, J.P. and J.S. Takahashi.  1996.  Regulation of the vgf gene in the hamster suprachiasmatic nucleus by light and by the circadian clock.  Journal of Comparative Neurology  378:229-238.

  86. Zhang, Y., J.S. Takahashi and F.W. Turek.  1996.  Critical period for cycloheximide blockade of light-induced phase advances of circadian locomotor activity rhythms in golden hamsters.  Brain Research  740:285-290.

  87. Takahashi, J.S.  1996.  The biological clock: it's all in the genes.  In: Progress in Brain Research, Vol. 111, Hypothalamic Integration of Circadian Rhythms.  R.M. Buijs, A. Kalsbeck, H.J. Romijn, C.M.A. Pennartz and M. Mirmiran (eds.), Elsevier Science BV, Amsterdam,  pp. 5-9.

  88. Kornhauser, J.M., D.D. Ginty, M.E. Greenberg, K.E. Mayo and J.S. Takahashi.  1996.  Light entrainment and activation of signal transduction pathways in the SCN. In: Progress in Brain Research, Vol. 111, Hypothalamic Integration of Circadian Rhythms.  R.M. Buijs, A. Kalsbeck, H.J. Romijn, C.M.A. Pennartz and M. Mirmiran (eds.), Elsevier Science BV, Amsterdam,  pp. 133-146.

  89. Sangoram, A., J.C. Florez, D.P. King and J.S. Takahashi.  1996.  Forward genetics and positional cloning applied to circadian behavior.  In: 1996 Short Course 1 Syllabus. What's Wrong With My Mouse? New Interplays Between Mouse Genetics and Behavior.  Society for Neuroscience, Washington, D.C.

  90. King, D.P. and J.S. Takahashi.  1996.  Forward genetic approaches to circadian clocks in mice.  Cold Spring Harbor Symposium on Quantitative Biology LXI:295-302.

  91. Lin, J.T., J.M. Kornhauser, N.P. Singh, K.E. Mayo and J.S. Takahashi.  1997.  Visual sensitivities of nur77 (NGFI-B) and zif268 (NGFI-A) induction in the suprachiasmatic nucleus are dissociated from c-fos induction and behavioral phase-shifting responses.  Molecular Brain Research 46:303-310.

  92. *King, D.P., Y. Zhao, A.M. Sangoram, L.D. Wilsbacher, M. Tanaka, M.P. Antoch, T.D.L. Steeves, M.H. Vitaterna, J.M. Kornhauser, P.L. Lowrey, F.W. Turek and J.S. Takahashi.  1997.  Positional cloning of the mouse circadian Clock gene.  Cell 89:641-653.

  93. *Antoch, M.P., E.-J. Song, A.-M. Chang, M.H. Vitaterna, Y. Zhao, L.D. Wilsbacher, A.M. Sangoram, D.P. King, L.H. Pinto and J.S. Takahashi.  1997.  Functional identification of the mouse circadian Clock gene by transgenic BAC rescue.  Cell 89:655-667.

  94. King, D.P., M.H. Vitaterna, A.-M. Chang, W.F. Dove, L.H. Pinto, F.W. Turek and J.S. Takahashi.  1997.  The mouse Clock mutation behaves as an antimorph and maps within the W19H deletion, distal of Kit.  Genetics 146:1049-1060.

  95. Barrett, R.K., and J.S. Takahashi.  1997.  Lability of circadian pacemaker amplitude in chick pineal cells: A temperature-dependent process.  Journal of Biological Rhythms 12:309-318.

  96. Silva, A.J., E.M. Simpson, J.S. Takahashi, H.P. Lipp, S. Nakanishi, J.M. Wehner, K.P. Giese, T. Tully, P.F. Chapman, T. Abel, K. Fox, G. Seth, S. Itohara, R. Lathe, M. Mayford, J.O. McNamara, R.J. Morris, M. Picciotto, J. Roder, H.S. Shin, P.A. Slesinger, D.R. Storm, M.P. Stryker, S. Tonegawa, Y. Wang and D.P. Wolfer.  1997.  Mutant mice and neuroscience: recommendations concerning genetic background.  Neuron 19:755-759.

  97. Valentinuzzi, V.S., K. Scarbrough, J.S. Takahashi and F.W. Turek.  1997.  Effects of aging on the circadian rhythm of wheel-running activity in C57BL/6 mice.  American Journal of Physiology 273:R1957-R1964. 

  98. Florez, J.C., L.D. Wilsbacher and J.S. Takahashi.  1998.  Body Rhythms/Body Clocks.  In: Encyclopedia of Mental Health, Volume 1, H.S. Friedman (ed.), Academic Press, San Diego, pp. 267-284. 

  99. 2Gekakis, N., D. Staknis, H.B. Nguyen, F.C. Davis, L.D. Wilsbacher, D.P. King, J.S. Takahashi and C.J. Weitz.  1998.  Role of the CLOCK protein in the mammalian circadian mechanism.  Science 280:1564-1569.

  100. †Darlington, T.K., K. Wager-Smith, M.F. Ceriani, D. Staknis, N. Gekakis, T.D.L. Steeves, C.J. Weitz, J.S. Takahashi and S.A. Kay.  1998.  Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim.  Science 280:1599-1603.

  101. Shimomura, K., J.M. Kornhauser, J.P. Wisor, T. Umezu, S. Yamazaki, N.L. Ihara, J.S. Takahashi and M. Menaker.  1998.  Circadian behavior and plasticity of light-induced c-fos expression in suprachiasmatic nucleus of tau mutant hamsters. Journal of Biological Rhythms 13:305-314.

  102. Max, M., A. Surya, L. Ruis-Avila, J.S. Takahashi, R.F. Margolskee and B.E. Knox.  1998.  Light-dependent activation of rod transducin by pineal opsin.  Journal of Biological Chemistry 273:26820-26826. 

  103. Katzenberg, D., T. Young, L. Finn, L. Lin, D.P. King, J.S. Takahashi and E. Mignot.  1998.  A CLOCK polymorphism associated with human diurnal preferences.  Sleep 21:569-576.

  104. Wilsbacher, L.D., J.P. Wisor and J.S. Takahashi.  1998.  Strategies for dissecting the molecular mechanisms of mammalian circadian rhythmicity.  In: Handbook of Behavioral State Control: Cellular and Molecular Mechanisms, R. Lydic and H.A. Baghdoyan (eds.), CRC Press, Boca Raton, pp. 75-84.

  105. Wilsbacher, L.D. and J.S. Takahashi.  1998.  Circadian rhythms: molecular basis of the clock.  Current Opinion in Genetics and Development  8:595-602. 

  106. Low-Zeddies, S. and J.S. Takahashi.  1999.  Genetic influences on circadian rhythms in mammals.  In: The Handbook of Genetic Influences on Neural and Behavioral Functions, S.C. Maxson (ed.), CRC Press, Boca Raton, pp. 293-305.

  107. Wisor, J.P. and J.S. Takahashi.  1999.  Molecular genetic approaches to the identity and function of circadian clock genes.  In: Regulation of Sleep and Circadian Rhythms, F.W. Turek and P.C. Zee (eds.), Marcel Dekker, New York, pp. 369-395.

  108. Nikaido, S.S. and J.S. Takahashi.  1998.  Day/night differences in the stimulation of adenylate cyclase activity by calcium/calmodulin in chick pineal cell cultures: Evidence for circadian regulation of cyclic AMP. Journal of Biological Rhythms 13:479-493.

  109. Valentinuzzi, V.S., D.E. Kolker, M.H. Vitaterna, K. Shimomura, A. Whiteley, S. Low-Zeddies, F.W. Turek, E.A.M. Ferrari, R. Paylor and J.S. Takahashi.  1998.  Automated measurement of mouse freezing behavior and its use for quantitative trait locus analysis of contextual fear conditioning in (BALB/cJ X C57BL/6J)F2 mice.  Learning and Memory 5:391-403.

  110. Sangoram, A.M., L. Saez, M.P. Antoch, N. Gekakis, D. Staknis, A. Whiteley, E.M. Fruechte, M.H. Vitaterna, K. Shimomura, D.P. King, M.W. Young, C.J. Weitz and J.S. Takahashi.  1998.  Mammalian circadian autoregulatory loop: A Timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription.  Neuron 21:1101-1113.

  111. Thresher, R.J., M.H. Vitaterna, Y. Miyamoto, A. Kazantsev, D.S. Hsu, C. Petit, C.P. Selby, L. Dawut, O. Smithies, J.S. Takahashi and A. Sancar.  1998.  Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses.  Science 282:490-494.

  112. Herzog, E.D., J.S. Takahashi and G.D. Block.  1998. Clock controls circadian period in isolated suprachiasmatic nucleus neurons.  Nature Neuroscience 1:708-713.

  113. Zhang, Y., G.C. Brainard, P.C. Zee, L.H Pinto, J.S. Takahashi and F.W. Turek.  1998.  Effects of aging on lens transmittance and retinal input to the suprachiasmatic nucleus in golden hamster.  Neuroscience Letters 258:167-170.

  114. Steeves, T.D.L., D.P. King, Y. Zhao, A.M. Sangoram, F. Du, A.M. Bowcock, R.Y. Moore and J.S. Takahashi.  1999.  Molecular cloning and characterization of the human CLOCK gene: Expression in the suprachiasmatic nucleus.  Genomics 57:189-200.

  115. Hahm, S., T.M. Mizuno, J. Wu, J.P. Wisor, C.A. Priest, C.A. Kozak, C.N. Boozer, B. Peng, R.C. McEvoy, P. Good, K.A. Kelley, J.S. Takahashi, J.E. Pintar, J.L. Roberts, C.V. Mobbs and S.R.J. Salton.  1999.  Targeted deletion of the vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of body weight and metabolism.  Neuron  23:537-548.

  116. Pinto, L.H. and J.S. Takahashi.  1999.  Genetic dissection of mouse behavior using induced mutagenesis. In: Handbook of Molecular-Genetic Techniques for Brain and Behavior Research, W.E. Crusio and R.T. Gerlai (eds.), Elsevier Science B.V., pp. 147-165.

  117. Nelson, D.E. and J.S. Takahashi.  1999.  Integration and saturation within the circadian photic entrainment pathway of hamsters.  American Journal of Physiology  277:R1351-R1361.

  118. Vitaterna, M.H., C.P. Selby, T. Todo, H. Niwa, C. Thompson, E.M. Fruechte, K. Hitomi, R.J. Thresher, T. Ishikawa, J. Miyazaki, J.S. Takahashi and A. Sancar. 1999.  Differential regulation of mammalian Period genes and circadian rhythmicity by Cryptochome 1 and 2.  Proc. Natl. Acad. Sci. USA 96:12114-12119.

  119. Takahashi, J.S.  1999.  Narcolepsy genes wake up the sleep field.  Science 285:2076-2077.

  120. Zhu, H., A. S. LaRue, A. Whiteley, T.D.L. Steeves, J.S. Takahashi and C.B. Green.  2000.  The Xenopus Clock gene is constitutively expressed in retinal photoreceptors.  Molecular Brain Research 75:303-308.

  121. Challet, E., J.S. Takahashi and F.W. Turek. 2000.  Nonphotic phase-shifting in Clock mutant mice.  Brain Research 859:398-403.

  122. King, D.P. and J.S. Takahashi.  2000.  Molecular genetics of circadian rhythms in mammals. Annual Review of Neuroscience 23:713-742.

  123. 3Lowrey, P.L., K. Shimomura, M.P. Antoch, S. Yamazaki, P.D. Zemenides, M.R. Ralph, M. Menaker and J.S. Takahashi. 2000. Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau.  Science 288:483-491.

  124. Hogenesch, J.B., Y.-Z. Gu, S.M. Moran, K. Shimomura, L.A. Radcliffe, J.S. Takahashi and C.A. Bradfield.  2000.  The basic helix-loop-helix-PAS protein MOP9 is a brain-specific heterodimeric partner  of circadian and hypoxia factors.  Journal of Neuroscience 2000, 0:RC83 (1-5).

  125. Valentinuzzi, V.S., O.M. Buxton, A. Chang, K. Scarbrough, E.A. Ferrari, J.S Takahashi and F. W Turek. 2000.  Locomotor response to an open field during C57BL/6J active and inactive phases: differences dependent on conditions of illumination. Physiology and Behavior 69:269-275.

  126. Lowrey, P.L. and J.S. Takahashi.  2000.  Genetics of the mammalian circadian system: Photic entrainment, circadian pacemaker mechanisms, and posttranslational regulation.  Annual Review of Genetics  34:533-562.

  127. Naylor, E., B.M. Bergmann, K. Krauski, P.C. Zee, J.S. Takahashi, M.H. Vitaterna and F.W. Turek.  2000.  The circadian Clock mutation alters sleep homeostasis in the mouse.  Journal of Neuroscience  20:8138-8143.

  128. Wilsbacher, L.D., A.M. Sangoram, M.P. Antoch and J.S. Takahashi.  2000.  The mouse Clock locus: Sequence and comparative analysis of 204 Kb from mouse chromosome 5. Genome Research 10:1928-1940.

  129. 4Bunger, M.K., L.D. Wilsbacher, S.M. Moran, C. Clendenin, L.A. Radcliffe, J.B. Hogenesch, M.C. Simon, J.S. Takahashi and C.A. Bradfield. 2000. Mop3 is an essential component of the master circadian pacemaker in mammals.  Cell 103:1009–1017.

  130. Valentinuzzi, V.S., D.E. Kolker, E.A. Ferrari, M.H. Vitaterna, J.S. Takahashi and F.W. Turek.  2001. Effect of circadian phase on context and tone fear conditioning in C57BL/6J mice.  Animal Learning and Behavior 29:133-142.

  131. Nadeau, J.H., R. Balling, G. Barsh, D. Beier, S. D. M. Brown, M. Bucan, S. Camper, G. Carlson, N. Copeland, J. Eppig, C. Fletcher, W.N. Frankel, D. Ganten, D. Goldowitz, C. Goodnow, J.-L. Guenet, G. Hicks, M. Hrabe de Angelis, I. Jackson, H.J. Jacob, N. Jenkins, D. Johnson, M. Justice, S. Kay, D. Kingsley, H. Lehrach, T. Magnuson, M. Meisler, A.M. Poustka, E.M. Rinchik, J. Rossant, L.B. Russell, J. Schimenti, T. Shiroishi, W.C. Skarnes, P. Soriano, W. Stanford, J.S. Takahashi, W. Wurst and A. Zimmer.  2001.  Sequence interpretation: Functional annotation of mouse genome sequences.  Science 291:1251-1255.

  132. Allada, R., P. Emery, J.S. Takahashi and M. Rosbash. 2001. Stopping time:  The genetics of fly and mouse circadian clocks.  Annual Review of Neuroscience 24:1091-119.

  133. 5Low-Zeddies, S.S. and J.S. Takahashi. 2001. Chimera analysis of the Clock mutation in mice shows that complex cellular integration determines circadian behavior.  Cell 105:25-42.

  134. 6Shimomura, K., S.S. Low-Zeddies, D.P. King, T.D.L. Steeves, A. Whiteley, J. Kushla, P.D. Zemenides, A. Lin, M.H. Vitaterna, G.A. Churchill and J.S. Takahashi.  2001.  Genome-wide epistatic interaction analysis reveals complex genetic determinants of circadian behavior in mice.  Genome Research 11:959-980.

  135. Reid, K.J., A.-M. Chang, M.L. Dubocovich, F.W. Turek, J.S. Takahashi and P.C. Zee. 2001.  Familial advanced sleep phase syndrome.  Archives of Neurology 58:1089-1094.

  136. Pinto, L.H. and J.S. Takahashi.  2001.  Functional identification of neural genes.  In: Methods in Genomic Neuroscience, H.R. Chin. and S.O. Moldin (eds.), CRC Press, Boca Raton, pp. 65-90.

  137. Vitaterna, M.H., J.S. Takahashi and F.W. Turek. 2001.  Overview of circadian rhythms. Alcohol Research and Health 25:85-93.

  138. Wilsbacher, L.D., S. Yamazaki, E.D. Herzog, E.J. Song, L.A. Radcliffe, M. Abe, G. Block, E. Spitznagel, M. Menaker and J.S. Takahashi. 2002.  Photic and circadian expression of luciferase in mPeriod1-luc transgenic mice in vivo. Proc. Natl. Acad. Sci. USA 99:489-494.

  139. 7 Panda, S., M.P. Antoch, B.H. Miller, A.I. Su, A.B. Schook, M. Straume, P.G. Schultz, S.A. Kay, J.S. Takahashi and J.B. Hogenesch. 2002.  Coordinated transcription of key pathways in the mouse by the circadian clock. Cell 109:307-320.

  140. Rosbash, M. and J.S. Takahashi. 2002.  Circadian rhythms:  The cancer connection. Nature 28:373-374.

  141. Lin, L., J. Wisor, T. Shiba, S. Taheri, K. Yanai, S. Wurts, X.Lin, M. Vitaterna, J. Takahashi, T.W. Lovenberg, M. Koehl, G. Uhl, S. Nishino and E. Mignot.  2002.  Measurement of hypocretin/orexin content in the mouse brain using an enzyme immunoassay: the effect of circadian time, age and genetic background.  Peptides 23:2203-2211.

  142. Merikangas, K.R, A. Chakravarti, S.O. Moldin, H. Araj, J.C. Blangero, M. Burmeister, J. Crabbe Jr, J.R. Depaulo Jr, E. Foulks, N.B. Freimer, D.S. Koretz, W. Lichtenstein, E. Mignot, A.L. Reiss, N.J. Risch and J.S. Takahashi.  2002.  Future of genetics of mood disorders research.  Biological  Psychiatry 52:457-477.

  143. Kolker, D.E., H. Fukuyama, D.S. Huang, J.S. Takahashi, T.H. Horton and F.W. Turek.  2003.  Aging alters circadian and light induced expression of clock genes in golden hamsters.  Journal of Biological Rhythms 18:159-169.

  144. Solberg, L.C., N. Ahmadiyeh, A.E. Baum, M.H. Vitaterna, J.S. Takahashi, F.W. Turek and E. Redei.  2003.  Depressive-like behavior and stress reactivity are independent traits in a Wistar Kyoto x Fisher 344 cross.  Molecular Psychiatry 8:423-433.

  145. Zambon, A.C., E.L., McDearmon, N. Salomonis, K.M. Vranizan, K.L. Johansen, D. Adey, J.S. Takahashi, M. Schambelan and B.R. Conklin. 2003. Time- and exercise-dependent gene regulation in human skeletal muscle. Genome Biology 4:R61.1-R61.11.

  146. Meijer, J.H. and J.S. Takahashi. 2003. Light responsiveness and photic entrainment of the mammalian circadian clock.  In: The Visual Neurosciences, L.M. Chalupa and J.S. Werner (eds.), MIT Press, pp. 625-640.

  147. Ahmadiyeh, N., G.A. Churchill, K. Shimomura, L.C. Solberg, J.S. Takahashi, J.S and E.E. Redei.  2003.  X-linked and lineage-dependent inheritance of coping responses to stress.  Mammalian Genome 14:748-757.

  148. Hogenesch, J.B., S. Panda, S. Kay and J.S. Takahashi.  2003.  Circadian transcriptional output in the SCN and liver of the mouse.  Novartis Foundation Symposium 253:171-180.

  149. 8Hong, H.-K., A. Chakravarti, and J.S. Takahashi.  2004.  The gene for soluble N-ethylmaleimide sensitive factor (NSF) attachment protein a (a-SNAP) is mutated in hydrocephaly with hop gait (hyh) mice.  Proc. Natl. Acad. Sci. USA 101:1748-1753.

  150. Kolker, D.E, M.H. Vitaterna, E.M Fruechte, J.S. Takahashi and F.W. Turek.  2004.  Effects of age on circadian rhythms are similar in wild-type and heterozygous Clock mutant mice.  Neurobiology of Aging 25:517-523.

  151. 9Yoo, S.-H., S. Yamazaki, P.L. Lowrey, K. Shimomura, C.H. Ko, E.D. Buhr, S.M. Siepka, H.-K. Hong, W.-J. Oh, O.-J. Yoo, M. Menaker and J.S. Takahashi.  2004. PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues.  Proc. Natl. Acad. Sci. USA 101:5339-5346.

  152. Ahmadiyeh, N., J.L. Slone-Wilcoxon, J.S. Takahashi and E.E. Redei.  2004.  Maternal behavior modulates X-linked inheritance of behavioral coping in the defensive burying test.  Biological Psychiatry  55:1069-1074.

  153. Solberg, L.C., A.E. Baum, N. Ahmadiyeh, K. Shimomura, R. Li, F.W. Turek, G.A. Churchill, J.S. Takahashi and E.E. Redei.  2004. Sex- and lineage-specific inheritance of depression-like behavior in the rat.  Mammalian Genome 15:648-662.

  154. Bult, C., W.A. Kibbe, J. Snoddy, M. Vitaterna, D. Swanson, S. Pretel, Y. Li, M.M. Hohman, E. Rinchik, J.S. Takahashi, W.N. Frankel and D. Goldowitz.  2004.  A genome end-game: understanding gene function in the nervous system.  Nature Neuroscience 7:484-485.

  155. Miller, B.H., S-L. Olson, F.W. Turek, J.E. Levine, T.H. Horton and J.S. Takahashi.  2004.  Circadian Clock mutation disrupts estrous cyclicity and maintenance of pregnancy.  Current Biology 14:1367-1373.

  156. Takahashi, J.S.  2004.  Finding new clock components: Past and future.  Journal of Biological Rhythms 19:339-347.

  157. Lowrey, P.L. and J.S. Takahashi. 2004.  Mammalian circadian biology: Elucidating genome-wide levels of temporal organization.  Annual Review of Genomics and Human Genetics  5:407-441.

  158. Pinto, L.H., M.H. Vitaterna, S.M. Siepka, K. Shimomura, S. Lumayag, M. Baker, D. Fenner, R.F. Mullins, V.C. Sheffield, E.M. Stone, E. Heffron and J.S. Takahashi.  2004.  Results from screening over 9000 mutation-bearing mice for defects in the electroretinogram and appearance of the fundus.  Vision Research 44:3335-3345.

  159. Triqueneaux, G., S. Thenot, T. Kakizawa, M.P. Antoch, R. Safi, J.S. Takahashi, F. Delaunay and V. Laudet.  2004.  The orphan receptor Rev-erbagene is a target of the circadian clock pacemaker.  Journal of Molecular Endocrinology 33:585-608.

  160. Goldowitz, D., W.N. Frankel, J.S. Takahashi, M.H. Vitaterna, C. Bult, W.A. Kibbe, J. Snoddy, Y. Li,  S. Pretel,  J. Yates and D.J. Swanson.  2004.  Large-scale mutagenesis of the mouse to understand the genetic bases of nervous system structure and function. Molecular Brain Research 132:105-115.

  161. 10Welsh, D.K., S-H. Yoo, A.C. Liu, J.S. Takahashi and S.A. Kay.  2004.  Bioluminescence imaging of individual fibroblasts reveals persistent, independently phased circadian rhythms of clock gene expression.  Current Biology 14:2289-2295.

  162. Clark, A.T., D. Goldowitz, J.S. Takahashi, M.H. Vitaterna, S.M. Siepka, L.L. Peters, W.N. Frankel, G.A. Carlson, J. Rossant, J. Nadeau, and M.J. Justice.  2004.  Implementing large-scale ENU mutagenesis screens in North America.  Genetica 122:51-64.

  163. Baum A.E., L.C. Solberg, P. Koop, N. Ahmadiyeh, G. Churchill, J.S. Takahashi, J.L. Jameson and E.E. Redei.  2005.  Quantitative trait loci associated with elevated TSH in the Wistar-Kyoto rat.  Endocrinology 146:870-878.

  164. Prolo, L.M., J.S. Takahashi and E.D. Herzog. 2005.  Circadian rhythm generation and entrainment in astrocytes.  Journal of Neuroscience 25:404-408.

  165. Ahmadiyeh, N., G.A. Churchill, L.C. Solberg, A.E. Baum, K. Shimomura, J.S. Takahashi and E.E. Redei.  2005.  Lineage is an epigenetic modifier of QTL influencing behavioral coping with stress.  Behavior Genetics 35:189-198. 

  166. 11Gorbacheva, V.Y., R.V. Kondratov, R. Zhang, S. Cherukuri, A.V. Gudkov, J.S. Takahashi and M.P. Antoch. 2005.  Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex.  Proc. Natl. Acad. Sci. USA 102:3407-3412.

  167. Yoo, S.-H., C.H. Ko, P.L. Lowrey, E.D. Buhr, E-J. Song, S. Chang, O.J. Yoo, S. Yamazaki, C. Lee and J.S. Takahashi. 2005.  A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo.  Proc. Natl. Acad. Sci. USA 102:2608-2613.

  168. Siepka, S.M. and J.S. Takahashi.  2005.  Forward genetic screen to identify circadian rhythm mutants in mice.  In: M. Young (ed.) Methods in Enzymology, Circadian Rhythms, 393:219-229, Elsevier Academic Press.

  169. Siepka, S.M. and J.S. Takahashi.  2005.  Methods to record circadian rhythm wheel running activity in mice.  In: M. Young (ed.) Methods in Enzymology, Circadian Rhythms, 393:230-239, Elsevier Academic Press.

  170. Yamazaki, S. and J.S. Takahashi. 2005.  Real-time luminescence reporting of circadian gene expression in mammals.  In:M. Young (ed), Methods in Enzymology, Circadian Rhythms, 393:288-301, Elsevier Academic Press.

  171. Low-Zeddies, S.S. and J.S. Takahashi.  2005.  Mouse chimeras and their application to circadian biology.  In: M. Young (ed), Methods in Enzymology, Circadian Rhythms, 393:478-492,Elsevier Academic Press.

  172. 12Turek, F.W., C. Joshu, A. Kohsaka, E. Lin, G. Ivanova, E. McDearmon, A. Laposky, S-L. Olson, A. Easton, D.R. Jensen, R.H. Eckel, J.S. Takahashi and J. Bass.  2005.  Obesity and metabolic syndrome in circadian Clock mutant mice.  Science 308:1043-1045.

  173. McClung, C.A., K. Sidiropoulou, M. Vitaterna, J.S. Takahashi, F.J. White, D.C. Cooper and E.J. Nestler.  2005.  Regulation of dopaminergic transmission and cocaine reward by the Clock gene.  Proc. Natl. Acad. Sci. USA 102:9377-9381.

  174. Brzezinski, J.A. IV, N.L. Brown, A. Tanikawa, R.A. Bush, P.A. Sieving, M.H. Vitaterna, J.S. Takahashi and T. Glaser.  2005.  Loss of circadian photoentrainment and abnormal retinal electrophysiology in Math5 mutant mice.  Investigative Ophthalmology and Visual Science 46:2540-2551.

  175. Antoch, M.P., R.V. Kondratov and J.S. Takahashi.  2005.  Circadian clock genes as modulators of sensitivity to genotoxic stress.  Cell Cycle 4:7 901-907.

  176. Pinto, L.H., M.H. Vitaterna, K. Shimomura, S.M. Siepka, E.L. McDearmon, D. Fenner, S. L. Lumayag, C. Omura, A.W. Andrews, Matthew Baker, B.M. Invergo, M.A. Olvera, E. Heffron, R.F. Mullins, V.C. Sheffield, E.M. Stone and J.S. Takahashi.  2005.  Generation, characterization, and molecular cloning of the Noerg-1 mutation of rhodopsin in the mouse.  Visual Neuroscience 22:619-629.

  177. Moran, J.L., A.D. Bolton, P.V. Tran, A. Brown, N.D. Dwyer, D.K. Manning, B.C. Bjork, C. Li, K. Montgomery, S.M. Siepka, M.H. Vitaterna, J.S. Takahashi, T. Wiltshire, D.J. Kwiatkowski, R. Kucherlapati and D.R. Beier.  2006. Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse.  Genome Research 16:436-440.

  178. Baum, A., L.C. Solberg, G.A. Churchill, N. Ahmadiyeh, J.S. Takahashi and E. Redei.  2006.  Test- and behavior-specific genetic factors affect WKY hypoactivity in tests of emotionality.  Behavioural Brain Research 169:220-230.

  179. Vitaterna, M.H., L.H. Pinto and J.S. Takahashi. 2006. Large-scale mutagenesis and phenotypic screens for the nervous system and behavior in mice. Trends in Neuroscience 29:233-240.

  180. Vitaterna, M.H., C.H. Ko, A.M. Chang, E.D. Buhr, E.M. Fruechte, A. Schook, M.P. Antoch, F.W. Turek and J.S. Takahashi. 2006. The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase-response curve amplitude. Proc Natl Acad Sci USA 103:9327-9332.

  181. Meredith, A.L., S.W. Wiler, B.H. Miller, J.S. Takahashi, A.A. Fodor, N.F. Ruby and R.W. Aldrich. 2006. BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output. Nature Neuroscience 9:1041-1049.

  182. Miller, B.H., S-L. Olson, J.E. Levine, F.W. Turek, T.H. Horton and J.S. Takahashi.  2006.  Vasopressin regulation of the proestrous luteinizing hormone surge in wildtype and Clock mutant mice.  Biology of Reproduction 75:778-784.

  183. Green, C.B. and J.S. Takahashi. 2006. Xenobiotic metabolism in the fourth dimension: PARTners in time.  Cell Metabolism 4:3-4.

  184. Ko, C.H. and J.S. Takahashi.  2006.  Molecular components of the mammalian circadian clock.  Human Molecular Genetics 15:R271-R277.

  185. Solberg, L.C., A.E. Baum, N. Ahmadiyeh, K. Shimomura, R. Li, F.W. Turek, J.S. Takahashi, G.A. Churchill and E.E. Redei.  2006.  Genetic analysis of the stress-responsive adrenocortical axis.  Physiological Genomics 27:362-369.

  186. McDearmon, E.L., K.N. Patel, C.H. Ko, J.A. Walisser, A.C. Schook, J.L. Chong, L.D. Wilsbacher, E-J Song, H-K Hong, C.A. Bradfield, and J.S. Takahashi.  2006.  Dissecting the functions of the mammalian clock protein BMAL1 by tissue-specific rescue in mice.  Science 314:1304-1308.

  187. Miller, B.H., E.L. McDearmon and J.S. Takahashi. 2007.  Chapter 22, The mammalian circadian system: From genes to behavior. In: A. Lajtha (ed.) and J.D. Blaustein (volume ed.), Handbook of Neurochemistry, and Molecular Neurobiology, 3rd Edition: Behavioral Neurochemistry and Neuroendocrinology,Springer-Verlag, Berlin Heidelberg, pp. 801-834. 

  188. Mignot, E. and J.S. Takahashi. 2007.  A circadian sleep disorder reveals a complex clock.  Cell 128:22-23.

  189. Kornmann, B., O. Schaad, H. Bujard, J.S. Takahashi and U. Schibler. 2007. System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock. PLoS Biology 5:179-189 [5(2): e34. doi:10.1371/journal.pbio.0050034].

  190. Miller, B.H., E.L. McDearmon, S. Panda, K.R. Hayes, J. Zhang, J.L. Andrews, M.P. Antoch, J.R. Walker, K.A. Esser, J.B. Hogenesch and J.S. Takahashi. 2007. Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation. Proc. Natl. Acad. Sci. USA 104:3342-3347.

  191. Hong, H.-K., J.L. Chong, W. Song, E.J. Song, A.A. Jyawook, A.C. Schook, C.H. Ko and J.S. Takahashi. 2007. Inducible and reversible Clock gene expression in brain using the tTA system for the study of circadian behavior. PLoS Genetics 3:324-338 [3(2): e33. doi:10.1371/journal.pgen.0030033].

  192. Roybal, K., D. Theobold, A. Graham, J.A. Dinieri, S.J. Russo, V. Krishnan, S. Chakravarty, J. Peevey, N. Oehrlein, S. Birnbaum, M.H. Vitaterna, P. Orsulak, J.S. Takahashi, E.J. Nestler, W.A. Carlezon Jr and C.A. McClung. 2007. Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci USA 104:6406-6411.

  193. McClurg, P., J. Janes, C. Wu, D.L. Delano, J.R. Walker, S. Batalov, J.S. Takahashi, K. Shimomura, A. Kohsaka, J. Bass, T. Wiltshire and A. Su. 2007. Genome-wide association analysis in diverse inbred mice: power and population structure. Genetics 10.1534/genetics.106.066241.

  194. Pinto, L.H., M.H. Vitaterna, K. Shimomura, S.M. Siepka, V. Balannik, E.L. McDearmon, C. Omura, S. Lumayag, B.M. Invergo, B. Glawe, D.R. Cantrell, S. Inayat, M.A. Olvera, K.A. Vessey, M.A. McCall, D. Maddox, C.W. Morgans, B. Young, M.T. Pletcher, R.F. Mullins, J.B. Troy and J.S. Takahashi. 2007. Generation, identification and functional characterization of the nob4 mutation in Grm6 in the mouse. Visual Neuroscience 24:111-123.

  195. Liu, A.C. D.K. Welsh, C.H. Ko, H.G. Tran, E.E. Zhang, A.A. Priest, E.D. Buhr, O. Singer, K. Meeker, I.M. Verma, F.J. Doyle,III, J.S. Takahashi and S.A Kay.  2007. Intercellular coupling confers robustness against mutations in the SCN circadian clock network. Cell 129:605-616.

  196. Siepka, S.M., S.-H. Yoo, J. Park, W. Song, V. Kumar, Y. Hu, C. Lee and J.S. Takahashi. 2007. Circadian mutant Overtime reveals F-box protein FBXL3 regulation of Cryptochrome and Period gene expression. Cell doi:10.10/16/jcell.2007.04.030.

1This article was featured in Trends in Neuroscience (by C.P. Kyriacou, Vol. 17, pp. 313-314, 1994) and in the Trends in Genetics Monitor (Vol. 10, p. 229, 1994).

*These articles were featured in Cell (Minireview, S.M. Reppert and D.R. Weaver, 89:487-490, 1997), Nature Medicine (News & Views, W.J. Schwartz, 3:718-719, 1997), as well as news stories in Science, Science News, NewScientist and J. NIH Research.  Selected as a ‘Hot Paper,’ E. Russo, The Scientist 13:16, 1999.

2These articles were featured in Nature (News & Views, U. Schibler, 393:620-21, 1998); Science (Perspective, J. Dunlap, 280:1548-49, 1998); and Neuron (S.M. Reppert, 21:1-4, 1998).

3This article was featured in a Science Perspective (M.W. Young, 288:45, 2000), a Trends in Genetics article (A.S.I. Loudon et al., 16:477, 2000), and was selected as a ‘Hot Paper,’ K.Y. Kreeger, The Scientist 16:32, 2002.

4Featured in S.A. Brown and U. Schibler, Current Biology 11:R268-70, 2001.

5Featured in U. Albrecht, Current Biology 11:R517-19, 2001; and E.R. Winstead, Genome News Network, May 14, 2001

6Featured in M. Patterson, Nature Reviews Genetics 2:487, 2001; N. Salathia, K. Edwards, A.J. Millar, Trends in Genetics 18: 115-118, 2002; and E.R, Winstead, Genome News Network, July 9, 2001.

7Highlighted by J.C. Lopez, Nature Reviews Neuroscience 3:418, 2002; M. Skipper, Nature Reviews Genetics 3:411, 2002; and F. Delaunay and V. Laudet, Trends in Genetics 18:595-97, 2002.

8Highlighted in a commentary by T.H. Sollner, PNAS 101:1431-1432, 2004.

9Highlighted in a commentary by R. Brandstaetter, PNAS 101:5699-5700, 2004.

10Featured in M. Hastings, Current Biology 15:R16-18, 2005.

11Highlighted in a commentary by C.B. Green, PNAS 102:3529-3530, 2005.

12Previewed in a commentary by D.L. Williams and M.W. Schwartz, Cell Metabolism 1:355-356, 2005.

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