Retinal microenvironment

We are interested in the microenvironment in which the neurons of the retina work. Studying the distribution and regulation of ions, substrates and metabolites allows us to understand aspects of cell biology, physiology and energy metabolism in the intact retina. Also, many blinding diseases are caused by problems with the vasculature and its ability to supply nutrients to the tissue. Our work provides insight into these diseases.
The focus of our current work is to understand the relationships between oxidative and glycolytic metabolism in the retina, and to work on animal models for diseases such as retinal vascular occlusion, diabetic retinopathy, and photoreceptor degenerations.

e-mail Dr. Linsenmeier
ph: 847.491.3043
fax: 847.491.4928

Selected References:

• Crosson LA, Kroes RA, Moskal JR, Linsenmeier RA. (2009). Gene expression patterns in hypoxic and post-hypoxic adult rat retina with special reference to the NMDA receptor and its interactome. Mol Vis. 15:296-311. Epub 2009 Feb 9.

• Budzynski E, Smith JH, Bryar P, Birol G, Linsenmeier RA. (2008). Effects of photocoagulation on intraretinal PO2 in cat. Invest Ophthalmol Vis Sci. 49(1):380-9.

• Chung CK, Linsenmeier RA. (2007). Effect of carbogen (95% O2/5% CO2) on retinal oxygenation in dark-adapted anesthetized cats. Curr Eye Res. 32(7-8):699-707.

• Birol G, Wang S, Budzynski E, Wangsa-Wirawan ND, Linsenmeier RA. (2007). Oxygen distribution and consumption in the macaque retina. Am J Physiol Heart Circ Physiol. 293(3):H1696-704.

• Wang S, Linsenmeier RA. (2007). Hyperoxia improves oxygen consumption in the detached feline retina. Invest Ophthalmol Vis Sci. 48(3):1335-41.

• Padnick-Silver L, Kang Derwent JJ, Giuliano E, Narfström K, Linsenmeier RA. (2006). Retinal oxygenation and oxygen metabolism in Abyssinian cats with a hereditary retinal degeneration. Invest Ophthalmol Vis Sci. 47(8):3683-9.

• Kang Derwent JJ, Padnick-Silver L, McRipley M, Giuliano E, Linsenmeier RA, Narfström K. (2006). The electroretinogram components in Abyssinian cats with hereditary retinal degeneration. Invest Ophthalmol Vis Sci. 47(8):3673-82.

• Padnick-Silver L, Linsenmeier RA. (2005). Effect of hypoxemia and hyperglycemia on pH in the intact cat retina. Arch Ophthalmol.123(12):1684-90.

• Budzynski E, Wangsa-Wirawan N, Padnick-Silver L, Hatchell D, Linsenmeier R. (2005). Intraretinal pH in diabetic cats. Curr Eye Res. 30(3):229-40.

• Birol G, Budzynski E, Wangsa-Wirawan ND, Linsenmeier RA. (2005). Retinal arterial occlusion leads to acidosis in the cat. Exp Eye Res. 80(4):527-33.

• Birol G, Budzynski E, Wangsa-Wirawan ND, Linsenmeier RA. (2004). Hyperoxia promotes electroretinogram recovery after retinal artery occlusion in cats. Invest Ophthalmol Vis Sci. 45(10):3690-6.

Other Links:

• Northwestern University Biomedical Engineering Department