Computational Neuroscience

With Nelson Spruston (Neurobiology & Physiology) and David Chopp (Applied Math) this NIH-funded project is an experimental and computational study of microcircuits composed of principal neurons and interneurons in the CA1 region of the hippocampus. Computational models are being developed based on the latest data available from ongoing experimental studies, which include patch-clamp experiments measuring ionic conductances, calcium imaging, and full-cell morphological reconstructions.

e-mail Dr. Kath
ph: 847.491.3345
fax: 847.491.2178

Selected References:

• N.L. Golding, T.J. Mickus, Y.Katz, W.L. Kath, and N. Spruston. Factors mediating powerful voltage attenuation along CA1 pyramidal neuron dendrites. J. Physiology, 568 (2005), pp. 69-82.

• W.L. Kath. Computational modeling of dendrites. J. Neurobiology 64 (2005), pp 91-99.

• N. Spruston, W.L. Kath, Dendritic arithmetic, Nature Neuroscience 7 (2004), pp. 567-569.

• N. Golding, W.L. Kath and N. Spruston, Dichotomy of action potential backpropagation in CA1 pyramidal neuron dendrites, J. Neurophysiology, 86 (2001), pp. 2998-3010.

Other Links:

• Northwestern University Engineering Sciences and Applied Mathematics

• Center for Photonic Computing and Communication

• McCormick School of Engineering