Computational Neuroscience

With Nelson Spruston (Neurobiology & Physiology) and David Chopp (Applied Math) this NIH-funded project is an experimental and computational study of microcircuits composed of principal neurons and interneurons in the CA1 region of the hippocampus. Computational models are being developed based on the latest data available from ongoing experimental studies, which include patch-clamp experiments measuring ionic conductances, calcium imaging, and full-cell morphological reconstructions.

e-mail Dr. Kath
ph: 847.491.3345
fax: 847.491.2178

Selected References:

• Li J, Biondini G, Kath WL, Kogelnik H. (2008) Anisotropic hinge model for polarization-mode dispersion in installed fibers. Optics Letters. Aug 15;33(16):1924-6.

• Rempe MJ, Spruston N, Kath WL, Chopp DL. (2008) Compartmental neural simulations with spatial adaptivity. J Comput Neurosci. Online. [Full Text]

• Katz Y, Kath WL, Spruston N, Hasselmo ME. (2007) Coincidence detection of place and temporal context in a network model of spiking hippocampal neurons. PLoS Comput Biol. (12):e234.

• Kath WL, Ottino JM. Chemistry. Rhythm engineering. (2007) Science. 316(5833):1857-8.

• Horikis TP, Kath WL. (2006) Modal analysis of circular Bragg fibers with arbitrary index profiles. Opt Lett. 31(23):3417-9.

• Nicholson DA, Trana R, Katz Y, Kath WL, Spruston N, Geinisman Y. (2006) Distance-dependent differences in synapse number and AMPA receptor expression in hippocampal CA1 pyramidal neurons.
Neuron. 2006 50(3):431-42.

• N.L. Golding, T.J. Mickus, Y.Katz, W.L. Kath, and N. Spruston. (2005) Factors mediating powerful voltage attenuation along CA1 pyramidal neuron dendrites. J. Physiology, 568 pp. 69-82.

• W.L. Kath. (2005) Computational modeling of dendrites. J. Neurobiology 64 pp 91-99.

• N. Spruston, W.L. Kath, (2004) Dendritic arithmetic, Nature Neuroscience 7 pp. 567-569.

• N. Golding, W.L. Kath and N. Spruston. (2001) Dichotomy of action potential backpropagation in CA1 pyramidal neuron dendrites, J. Neurophysiology, 86 pp. 2998-3010.

Other Links:

• Northwestern University Engineering Sciences and Applied Mathematics

• Center for Photonic Computing and Communication

• McCormick School of Engineering