Peter Dallos, Ph.D.





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Peter Dallos
		Biophysics and Neurobiology of the Cochlea Our work is focused on understanding the molecular and cellular bases of mammalian hearing. We focus on the functioning and role in the hearing process of the mammalian innovation: outer hair cells. These sensory receptors have motor capabilities and perform as the cochlear amplifier. Our latest work pertains to the study of the motor protein of outer hair cells. In 2000 we cloned the gene Prestin that codes for this molecular motor. When expressed in a heterologous cell system, prestin confers electromotility and nonlinear charge movement. We now study the properties of prestin and the electrophysiology of prestin knockout and knockin mice.
John Evans Professor PhD, Northwestern
e-mail Dr. Dallos ph: 847.491.3175 fax: 847.467.4327
	Selected References: • Sengupta S, George M, Miller KK, Naik K, Chou J, Cheatham MA, Dallos P, Naramura M, Band H, Zheng J. (2009). EHD4 and CDH23 are interacting partners in cochlear hair cells. J Biol Chem. Jun 1. • Zheng J, Anderson CT, Miller KK, Cheatham M, Dallos P. (2009). Identifying components of the hair-cell interactome involved in cochlear amplification. BMC Genomics. Mar 25;10:127. • Dallos P. (2008). Cochlear amplification, outer hair cells and prestin. Curr Opin Neurobiol. 18(4):370-6. • Dallos P, Wu X, Cheatham MA, Gao J, Zheng J, Anderson CT, Jia S, Wang X, Cheng WH, Sengupta S, He DZ, Zuo J. (2008). Prestin-based outer hair cell motility is necessary for mammalian cochlear amplification. Neuron. 58(3):333-9. [Full Text]. • Wu X, Wang X, Gao J, Yu Y, Jia S, Zheng J, Dallos P, He DZ, Cheatham M, Zuo J. (2008). Glucose transporter 5 is undetectable in outer hair cells and does not contribute to cochlear amplification. Brain Research. 210:20-8. • Richter CP, Emadi G, Getnick G, Quesnel A, Dallos P. Tectorial membrane stiffness gradients. (2007). Biophysical Journal. 93(6):2265-76. • Jia S, Dallos P, He DZ. (2007). Mechanoelectric transduction of adult inner hair cells. Journal of Neuroscience. 27(5):1006-14. [Full Text]. • Dallos P, Zheng J, Cheatham MA. (2006). Prestin and the cochlear amplifier. The Journal of Physiology. (Pt 1):37-42. Review. • Zheng J, Du GG, Anderson CT, Keller JP, Orem A, Dallos P, Cheatham M. (2006). Analysis of the oligomeric structure of the motor protein prestin. Journal of Biological Chemistry. 281(29):19916-24. • Lu TK, Zhak S, Dallos P, Sarpeshkar R. (2006). Fast cochlear amplification with slow outer hair cells. Hearing Research. 214(1-2):45-67. • Zheng, J., G.G. Du, A. Orem, S. Aguiñaga, L.D. Madison, P. Dallos, (2005). The carboxy terminus of prestin influences both motor function and plasma membrane targeting. J. Cell Science. 118: 2987-2996. • Cheatham, M.A., Zheng, J., Huynh, K.H., Du, G.G., Zuo, J., Navarrete, E. and Dallos, P. (2005). Cochlear function in mice with only one copy of the Prestin gene. J. Physiol. (London) 569.1: 229-241. • Deák, L.J. Zheng, S., Aguiñaga, A. Orem, G.G. Du, K. Matsuda, P. Dallos. (2005). Effects of cyclic nucleotides on prestin's function. J Physiol. (London) 563.2: 483-496. • He, D.Z.Z., S. Jia, P. Dallos. (2004). Mechanoelectrical transduction of adult outer hair cells studied in the hemicochlea. Nature. 429: 766-770. • Cheatam, M.A., K.H. Huynh, J. Gao, J. Zuo, P. Dallos. (2004). Cochlear function in Prestin knockout mice. J. Physiol. (London) 560.3: 821-830. • Matsuda, K., J. Zheng, G.G. Du, N. Klöcker, L.D. Madison, P. Dallos. (2004). N-linked glycosylation sites of the motor protein prestin: effects on electrophysiological function. J. Neurochem. 89:928-938. • Oliver, D., D.Z.Z. He, N. Klöcker, J. Ludwig, U. Schulte, S. Waldegger, J.P. Ruppersberg, P. Dallos, and B. Fakler. (2001). Intracellular anions as the voltage-sensor of prestin, the outer hair cell motor protein. Science 292, 2340-2343 [full text]. • Santos-Sacchi, J., Shen, W., Zheng, J. and Dallos, P. (2001). Effects of membrane potential and tension on prestin, the outer hair cell membrane protein. J. Physiol. (London) 531, 661-666. [full text]. • Zheng, J., W. Shen, D.Z.Z. He, K. Long, L.D. Madison and P. Dallos. (2000). Prestin is the motor protein of cochlear outer hair cells. Nature 405, 149-155. [full text]. • He, D.Z.Z. and P. Dallos. (1999). Somatic stiffness of cochlear outer hair cells is voltage dependent. Proc.Natl.Acad.Sci.USA 96: 8223-8228. [full text].		Other Links: • link to a more detailed research description • Northwestern University School of Speech • Northwestern Institute for Neuroscience (NUIN)